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. 1975;290(2-3):323-7.
doi: 10.1007/BF00510561.

Decreased glycolytic flux rate in the isolated perfused rat brain after pretreatment with 6-aminonicotinamide

J Krieglstein, R Stock

Decreased glycolytic flux rate in the isolated perfused rat brain after pretreatment with 6-aminonicotinamide

J Krieglstein et al. Naunyn Schmiedebergs Arch Pharmacol. 1975.

Abstract

Cerebral energy metabolism was studied in the isolated perfused rat brain after 6-aminonicotinamide (6-AN; 35 mg/kg i.p.) administered to the intact animals 7 hrs before perfusion was started. The metabolic alterations in the isolated rat brains were such as reported for rat and mouse brain in vivo: Inhibition of 6-phosphogluconate dehydrogenase was followed by an accumulation of 6-phosphogluconate, leading to a decreased activity of glucosephosphate isomerse. This was reflected by increased levels of glucose and glucose 6-phosphate and decreased levels of fructose 6-phosphate, pyruvate and lactate. Since the concentration of lactate in the perfusate of the isolated brain was also lowered, 6-AN must have reduced the glycolytic flux rate.

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