Review
doi: 10.1016/s1367-5931(03)00027-9.
Missing genes in metabolic pathways: a comparative genomics approach
Affiliations
- PMID: 12714058
- DOI: 10.1016/s1367-5931(03)00027-9
Item in Clipboard
Review
Missing genes in metabolic pathways: a comparative genomics approach
Curr Opin Chem Biol.
2003 Apr.
Abstract
The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.
Similar articles
-
Using gene knockouts to investigate plant metabolism.J Exp Bot. 2001 Aug;52(361):1593-601. J Exp Bot. 2001. PMID: 11479324 Review.
-
Metabolic gene clusters encoding the enzymes of two branches of the 3-oxoadipate pathway in the pathogenic yeast Candida albicans.FEMS Yeast Res. 2015 May;15(3):fov006. doi: 10.1093/femsyr/fov006. Epub 2015 Mar 4. FEMS Yeast Res. 2015. PMID: 25743787
-
New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis.Chem Biol. 2002 Nov;9(11):1163-4. doi: 10.1016/s1074-5521(02)00267-3. Chem Biol. 2002. PMID: 12445765 No abstract available.
-
Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs.BMC Genomics. 2003 Jun 3;4(1):22. doi: 10.1186/1471-2164-4-22. Epub 2003 Jun 3. BMC Genomics. 2003. PMID: 12783626 Free PMC article.
-
Genome mining as a biotechnological tool for the discovery of novel marine natural products.Crit Rev Biotechnol. 2020 Aug;40(5):571-589. doi: 10.1080/07388551.2020.1751056. Epub 2020 Apr 19. Crit Rev Biotechnol. 2020. PMID: 32308042 Review.
Cited by
-
One pathway can incorporate either adenine or dimethylbenzimidazole as an alpha-axial ligand of B12 cofactors in Salmonella enterica.J Bacteriol. 2008 Feb;190(4):1160-71. doi: 10.1128/JB.01386-07. Epub 2007 Nov 2. J Bacteriol. 2008. PMID: 17981976 Free PMC article.
-
Systematizing the generation of missing metabolic knowledge.Biotechnol Bioeng. 2010 Oct 15;107(3):403-12. doi: 10.1002/bit.22844. Biotechnol Bioeng. 2010. PMID: 20589842 Free PMC article. Review.
-
Comparative genome analysis of four magnetotactic bacteria reveals a complex set of group-specific genes implicated in magnetosome biomineralization and function.J Bacteriol. 2007 Jul;189(13):4899-910. doi: 10.1128/JB.00119-07. Epub 2007 Apr 20. J Bacteriol. 2007. PMID: 17449609 Free PMC article.
-
Genome evolution reveals biochemical networks and functional modules.Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15428-33. doi: 10.1073/pnas.2136809100. Epub 2003 Dec 12. Proc Natl Acad Sci U S A. 2003. PMID: 14673105 Free PMC article.
-
Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.Front Microbiol. 2019 Jun 12;10:1316. doi: 10.3389/fmicb.2019.01316. eCollection 2019. Front Microbiol. 2019. PMID: 31275260 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
