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Review
. 2003 Apr;7(2):238-51.
doi: 10.1016/s1367-5931(03)00027-9.

Missing genes in metabolic pathways: a comparative genomics approach

Andrei Osterman  1 , Ross Overbeek
Affiliations
Review

Missing genes in metabolic pathways: a comparative genomics approach

Andrei Osterman et al. Curr Opin Chem Biol. 2003 Apr.

Abstract

The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.

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