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. 2002 Dec;81(3):105-10.
doi: 10.1007/BF02715907.

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P Jain  1 , V Nagaraja
Affiliations

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P Jain et al. J Genet. 2002 Dec.

Abstract

DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

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