doi: 10.1073/pnas.72.8.2915.
DNA polyintercalating drugs: DNA binding of diacridine derivatives
- PMID: 127172
- PMCID: PMC432889
- DOI: 10.1073/pnas.72.8.2915
Item in Clipboard
DNA polyintercalating drugs: DNA binding of diacridine derivatives
Proc Natl Acad Sci U S A.
1975 Aug.
Abstract
As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been studied. It has been determined that when the chain separating the two aromatic rings is longer than a criticål distance, bisintercalation is actually observed and that the DNA binding affinity becomes quite large (greater than 10(8)-10(9) M-1). It is shown also that the optical characteristics of these molecules are dependent on the sequences of DNA. The fluorescence intensity of one of these dimers when bound to DNA varies as the fourth power of its A+T content. This derivative could be used as a fluorescent probe of DNA sequence.
Similar articles
-
Fluorescent conjugates of natural and biosynthetic polynucleotides.Biochim Biophys Acta. 1972 Aug 25;277(2):306-22. doi: 10.1016/0005-2787(72)90413-3. Biochim Biophys Acta. 1972. PMID: 5075289 No abstract available.
-
Isolation and characterization of self-complementary sequences from phiX174 viral DNA.J Mol Biol. 1975 Nov 25;99(1):93-105. doi: 10.1016/s0022-2836(75)80161-6. J Mol Biol. 1975. PMID: 128634 No abstract available.
-
An exonuclease of Neurospora crassa specific for single-stranded nucleic acids.Biochim Biophys Acta. 1972 Jan 18;259(1):50-68. doi: 10.1016/0005-2787(72)90473-x. Biochim Biophys Acta. 1972. PMID: 4334920 No abstract available.
-
Binding of netropsin to DNA and synthetic polynucleotides.Mol Biol Rep. 1974 Mar;1(6):337-42. doi: 10.1007/BF00309567. Mol Biol Rep. 1974. PMID: 4473703 No abstract available.
-
DNA stiffening and elongation caused by the binding of ethidium bromide.Biochim Biophys Acta. 1973 Aug 24;319(2):135-9. doi: 10.1016/0005-2787(73)90004-x. Biochim Biophys Acta. 1973. PMID: 4795895 No abstract available.
Cited by
-
Design of a new DNA-polyintercalating drug, a bisacridinyl peptidic analogue of Triostin A.Biochem J. 1985 Feb 1;225(3):829-32. doi: 10.1042/bj2250829. Biochem J. 1985. PMID: 3838469 Free PMC article.
-
Intracellular DNA damage produced by a series of diacridines.Biochem J. 1985 Feb 15;226(1):175-82. doi: 10.1042/bj2260175. Biochem J. 1985. PMID: 3977863 Free PMC article.
-
In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum.Antimicrob Agents Chemother. 2003 Jan;47(1):174-80. doi: 10.1128/AAC.47.1.174-180.2003. Antimicrob Agents Chemother. 2003. PMID: 12499188 Free PMC article.
-
Determination of molecular weights by fluctuation spectroscopy: application to DNA.Proc Natl Acad Sci U S A. 1976 Aug;73(8):2776-80. doi: 10.1073/pnas.73.8.2776. Proc Natl Acad Sci U S A. 1976. PMID: 822421 Free PMC article.
-
Free-radical-mediated DNA binding.Environ Health Perspect. 1985 Dec;64:219-32. doi: 10.1289/ehp.8564219. Environ Health Perspect. 1985. PMID: 3007090 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
