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Case Reports
. 2003 Jun;29(6):985-988.
doi: 10.1007/s00134-003-1748-5. Epub 2003 Apr 29.

Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Ravi R Thiagarajan  1   2 , Stephen J Roth  3   4 , Steven Margossian  5   4 , Andrew S Mackie  3   4 , Ellis J Neufeld  5   4 , Peter C Laussen  3   4 , Joseph M Forbess  6   4 , Elizabeth D Blume  3   4
Affiliations
Case Reports

Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Ravi R Thiagarajan et al. Intensive Care Med. 2003 Jun.

Abstract

Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy.

Design: Case report.

Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period.

Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.

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