Prolonged lifespan by defective insulin signalling?

Affiliations

Review

Jörg Dösch et al. Eur J Endocrinol. 2003 May.

. 2003 May;148(5):489-90.

doi: 10.1530/eje.0.1480489.

¹ Klinik fur Kinder und Jugendliche, Friedrich-Alexander-University Erlangen, Loschgestrasse 15D, 91054 Erlangen, Germany. JoergWDoetsch@yahoo.com

No abstract available

Comment in

Insulin, food restriction and the extension of lifespan: the mechanism of longevity.
Bergamini E, Cavallini G, Donati A, Gori Z. Bergamini E, et al. Eur J Endocrinol. 2004 Jan;150(1):95. doi: 10.1530/eje.0.1500095. Eur J Endocrinol. 2004. PMID: 14713285 No abstract available.

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Blüher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Blüher M, et al. Dev Cell. 2002 Jul;3(1):25-38. doi: 10.1016/s1534-5807(02)00199-5. Dev Cell. 2002. PMID: 12110165
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Blüher M, Kahn BB, Kahn CR. Blüher M, et al. Science. 2003 Jan 24;299(5606):572-4. doi: 10.1126/science.1078223. Science. 2003. PMID: 12543978