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Review
. 2003 Jun;7(3):212-7.
doi: 10.1007/s11916-003-0075-4.

Migraine genetics

Esther Kors  1 , Joost Haan, Michel Ferrari
Affiliations
Review

Migraine genetics

Esther Kors et al. Curr Pain Headache Rep. 2003 Jun.

Abstract

The genetics of migraine is a fascinating and moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene in approximately 75% of the families. The finding of mutations in an ionchannel subunit defines migraine as a channelopathy (eg, epilepsy). The genetics of the more frequent variants, migraine with and without aura, is more complex. Several loci have been studied in families and case-control studies, but need to be confirmed.

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