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Review
. 2003 May 13;100(10):5578-80.
doi: 10.1073/pnas.1132039100. Epub 2003 Apr 29.

A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis

Richard L Veech  1
Affiliations
Review

A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis

Richard L Veech. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Xu-5-P is the signal for the coordinated control of lipogenesis. Feeding carbohydrate causes levels of liver glucose, Glc-6-P, and Fru-6-P to rise. Elevation of [Fru-6-P] leads to elevation of [Xu-5-P] in reactions catalyzed by the near-equilibrium isomerases of the nonoxidative portion of the hexose monophosphate pathway. The elevation of [Xu-5-P] is the coordinating signal that both acutely activates PFK in glycolysis and promotes the action of the transcription factor ChREBP to increase transcription of the genes for the enzymes of lipogenesis, the hexose monophosphate shunt, and glycolysis, all of which are required for the de novo synthesis of fat. The figure depicts the increase in enzyme transcription caused by the carbohydrate response element binding protein, ChREBP, in green dashed lines. Stimulation of the Fru-2,6-kinase reaction by protein phosphatase 2A (PP2A) and its stimulation by Xu-5-P are by indicated green dotted lines. Metabolic reactions are indicated by solid black lines. Those reactions that are reversible in vivo are indicated with double arrows, and those catalyzing unidirectional reactions have only a single arrowhead. [ATP]/[ADP][Pi] represents the free cytosolic phosphorylation potential catalyzed by the combined glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and 3-phosphoglycerate kinase reactions, and [AMP] represents the free cytosolic value catalyzed by the myokinase reaction. The names and EC numbers of the enzymes in green are given in the text. Inhibitions by AMP-stimulated protein kinase and cAMP-stimulated protein kinase are indicted by red dotted lines.
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References

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