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Review
. 2003;5(3):139-46.
doi: 10.1186/ar757. Epub 2003 Apr 2.

Behçet's disease

Shunsei Hirohata  1 , Hirotoshi Kikuchi
Affiliations
Review

Behçet's disease

Shunsei Hirohata et al. Arthritis Res Ther. 2003.

Abstract

Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.

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Figures

Figure 1
Figure 1
Proposed model of the pathogenesis in Behçet's disease. Ag, antigen; APC, antigen-presenting cells; HSP, heat shock protein; IFN, interferon; IL, interleukin; IPP, isoprenyl pyrophosphate; PPP, prenyl pyrophosphate; TCR, T-cell receptor; Th1, T helper cells type 1; TNF-α, tumor necrosis factor alpha.
See this image and copyright information in PMC

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