Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Apr;9(4):169-76.
doi: 10.1016/s1471-4914(03)00031-5.

Protein carbonylation in human diseases

Isabella Dalle-Donne  1 , Daniela Giustarini, Roberto Colombo, Ranieri Rossi, Aldo Milzani
Affiliations
Review

Protein carbonylation in human diseases

Isabella Dalle-Donne et al. Trends Mol Med. 2003 Apr.

Abstract

Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis. Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.

PubMed Disclaimer

Publication types

LinkOut - more resources