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Review
. 2003 Apr:987:60-7.
doi: 10.1111/j.1749-6632.2003.tb06033.x.

Intrinsic T cell defects in systemic autoimmunity

Philip L Kong  1 , Jared M Odegard, Farida Bouzahzah, Jin-Young Choi, Leah D Eardley, Christina E Zielinski, Joseph E Craft
Affiliations
Review

Intrinsic T cell defects in systemic autoimmunity

Philip L Kong et al. Ann N Y Acad Sci. 2003 Apr.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.

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