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. 1976 Mar;3(3):709-20.
doi: 10.1093/nar/3.3.709.

The effective synthesis of uridylyl/3'-5'/5-methylcytidylyl/3'-5'/guanosine

K Golankiewicz, A Jankowski
Free PMC article

The effective synthesis of uridylyl/3'-5'/5-methylcytidylyl/3'-5'/guanosine

K Golankiewicz et al. Nucleic Acids Res. 1976 Mar.
Free PMC article

Abstract

The triester method was adapted to the synthesis of uridylyl/3'-5'/5-methylcytidylyl/3'-5'/guanosine. As the protecting groups 4-methoxy-5,6-dihydro-2H-pyran for 2'-OH and 5'-OH groups of uridine and 2'-OH group of 5-methylcytidine, methoxymethylidene for I:3'-cis-diol system of guanosine, and benzoyl for the amino groups of 5-methylcytidine and guanosine were used. The obtained product was characterised by UV, electrophoresis, chromatography, an enzymatic digestion and alkaline hydrolysis.

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References

    1. J Chem Soc Perkin 1. 1973;21:2513-7 - PubMed
    1. Tetrahedron. 1970 Feb;26(4):1023-30 - PubMed
    1. Chem Ber. 1967;100(7):2228-35 - PubMed
    1. Tetrahedron. 1967 May;23(5):2301-13 - PubMed
    1. Biochim Biophys Acta. 1960 Feb 12;38:176-8 - PubMed