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Review
. 2003 Apr;3(2):151-8.
doi: 10.1007/s11892-003-0039-4.

The genetics of adiponectin

Francis Vasseur  1 , Frédéric Leprêtre, Corinne Lacquemant, Philippe Froguel
Affiliations
Review

The genetics of adiponectin

Francis Vasseur et al. Curr Diab Rep. 2003 Apr.

Abstract

Adiponectin encoded by the APMI gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APMI gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APMI gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APMI gene and questions that genetic data raise.

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References

    1. Diabetes Care. 2002 Feb;25(2):376-80 - PubMed
    1. Diabetes. 2002 Aug;51(8):2341-7 - PubMed
    1. J Biol Chem. 1989 Apr 5;264(10):5488-94 - PubMed
    1. J Clin Endocrinol Metab. 2002 May;87(5):2395 - PubMed
    1. Lancet. 2002 Jul 6;360(9326):57-8 - PubMed

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