[The role of hormone replacement therapy in the treatment of women with complicated chronic renal failure]

Abstract

Patients with chronic renal failure (CRF) show an increased mortality and morbidity from cardiovascular disease. Women with CRF are also at high risk of accelerated bone loss and fracture because of complications such as renal osteodystrophy and many endocrine disturbances leading to premature menopause and estrogen deficiency. Hormone replacement therapy (HRT) has been known to have beneficial effects on various atherosclerotic parameters in population of postmenopausal women and its role in primary prevention of coronary artery disease has been proved in many studies. In general population estrogen replacement therapy has also been used as an effective form of treatment in women suffering from bone loss as well as a form of prevention of osteoporosis. Until now, the role of estrogen replacement therapy in the treatment of complications of end-stage renal disease in female patients has not been fully elucidated and the use of hormone replacement therapy needs to be carefully analysed in each individual case taking into account all risks and benefits.