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. 2003 May 30;300(5624):1394-9.
doi: 10.1126/science.1085952. Epub 2003 May 1.

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A Rota  1 , M Steven Oberste, Stephan S Monroe, W Allan Nix, Ray Campagnoli, Joseph P Icenogle, Silvia Peñaranda, Bettina Bankamp, Kaija Maher, Min-Hsin Chen, Suxiong Tong, Azaibi Tamin, Luis Lowe, Michael Frace, Joseph L DeRisi, Qi Chen, David Wang, Dean D Erdman, Teresa C T Peret, Cara Burns, Thomas G Ksiazek, Pierre E Rollin, Anthony Sanchez, Stephanie Liffick, Brian Holloway, Josef Limor, Karen McCaustland, Melissa Olsen-Rasmussen, Ron Fouchier, Stephan Günther, Albert D M E Osterhaus, Christian Drosten, Mark A Pallansch, Larry J Anderson, William J Bellini
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Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A Rota et al. Science. .

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

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