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. 2003 May;33(5):1439-49.
doi: 10.1002/eji.200323910.

Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

Paola Zaccone  1 , Zoltán Fehérvári, Frances M Jones, Stéphane Sidobre, Mitchell Kronenberg, David W Dunne, Anne Cooke
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Free article

Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

Paola Zaccone et al. Eur J Immunol. 2003 May.
Free article

Abstract

Infection with Schistosoma mansoni (S. mansoni) or exposure to eggs from this helminth inhibits the development of type 1 diabetes in NOD mice. In this study we show that soluble extracts of S. mansoni worm or egg completely prevent onset of type 1 diabetes in these mice but only if injection is started at 4 weeks of age. T cells from diabetes-protected mice make IL-10 in recall responses to parasite antigens. These cells are furthermore impaired in their ability to transfer diabetes to NOD-SCID recipients. Bone marrow dendritic cells derived from NOD mice are found to make more IL-10 and less IL-12 following culture with S. mansoni soluble egg antigens in conjunction with lipopolysaccharides. NOD mice are deficient in NKT cells. Soluble worm and egg antigens increase the numbers of V alpha 14i NKT cells in NOD mice. These effects of schistosome antigens on the innate immune system provide a mechanism for their ability to prevent type 1 diabetes in NOD mice.

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