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Comment
. 2003 May 2;113(3):278-80.
doi: 10.1016/s0092-8674(03)00309-x.

Coordinate regulation of an extended chromosome domain

Vincent C Calhoun  1 , Michael Levine
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Comment

Coordinate regulation of an extended chromosome domain

Vincent C Calhoun et al. Cell. .
Free article

Abstract

Spitz et al (2003[this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.

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