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. 2003 May 5;197(9):1065-71.
doi: 10.1084/jem.20030320.

Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year

Lawrence Steinman  1
Affiliations

Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year

Lawrence Steinman. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
In EAE T lymphocytes gain access to the CNS via their α4 integrins, recognizing VCAM on the blood vessel wall (references , , and 21). The T cells diapedese through the endothelium, using matrix metalloproteases to cleave collagen IV in the extracellular matrix (reference 4). Once within the CNS they release inflammatory cytokines. The B cell and the mast cell also contribute to pathology (reference 4). Complement plus antibody leads to activation of membrane attack complexes which attack the myelin sheath (reference 4). EAE can be blocked by an α4 integrin antibody (reference 20). Antegren which recognizes human α4 integrin has shown promise in phase II trials in MS (reference 21). Statins (reference 18) and altered peptide ligands (references and 52) can interfere with the recognition of myelin fragments by inducible MHC class II in the CNS (reference 4). Antihistamines and platelet activating receptor antagonists can block mast cell activity in EAE (reference 6).
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References

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    1. Bettelli, E., M. Pagany, H.L. Weiner, C. Linington, R.A. Sobel, and V.K. Kuchroo. 2003. Myelin oligodendroglial glycoprotein TCR transgenic mice develop spontaneous optic neuritis. J. Exp. Med. 197:1073–1081. - PMC - PubMed
    1. Steinman, L. 2000. Multiple sclerosis: a two stage disease. Nat. Immunol. 2:762–764. - PubMed
    1. Pedotti, R., D. Mitchell, J. Wedemeyer, M. Karpuj, D. Chabas, E. Hattab, M. Tsai, S.J. Galli, and L. Steinman. 2001. An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide. Nat. Immunol. 2:216–222. - PubMed

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