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Review
. 2003;4(5):214.
doi: 10.1186/gb-2003-4-5-214. Epub 2003 Apr 29.

The role of DNA sequence in centromere formation

Jonathan C Lamb  1 , James A Birchler
Affiliations
Review

The role of DNA sequence in centromere formation

Jonathan C Lamb et al. Genome Biol. 2003.

Abstract

Centromeres are key to the correct segregation and inheritance of genetic information. Eukaryotic centromeres, which are located in large blocks of highly repetitive DNA, have been notoriously difficult to sequence. Several groups have recently succeeded in analyzing centromeric sequences in human, Drosophila and Arabidopsis, providing new insights into the importance of DNA sequence for centromere function.

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