Acute flaccid paralysis from echovirus type 33 infection

Abstract

During a community echovirus type 33 outbreak, the virus was detected in the feces and cerebrospinal fluid of a 3-year-old boy with right arm weakness that followed a mild nonspecific febrile illness. This is the first time an association between echovirus type 33 infection and acute flaccid paralysis has been reported.

FIG. 1.

Specific amplification of E33 outbreak isolates by RT-PCR with the 158S-159A primer set. Lanes 1 to 12, clinical E33 isolates involved in an outbreak; lane N, negative control; lane M, molecular size marker.

FIG. 2.

Pairwise comparison of VP1 nucleotide sequences showing sequence differences between the E33 fecal isolate from the patient with AFP (NEZ00-812) and the E33 prototype strain, Toluca-3. The locations of diagnostic primers 158S and 159A are also indicated.