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Case Reports
. 2003 Jun;442(6):605-10.
doi: 10.1007/s00428-003-0807-1. Epub 2003 May 7.

Pleomorph poorly differentiated endocrine carcinoma of the rectum

Pellegrino Crafa  1 , Massimo Milione, Cinzia Azzoni, Francesco Paolo Pilato, Silvia Pizzi, Cesare Bordi
Affiliations
Case Reports

Pleomorph poorly differentiated endocrine carcinoma of the rectum

Pellegrino Crafa et al. Virchows Arch. 2003 Jun.

Abstract

We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.

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References

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