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Review
. 2004 Feb;447(5):543-8.
doi: 10.1007/s00424-003-1065-4. Epub 2003 May 7.

The sodium/calcium exchanger family-SLC8

Beate D Quednau  1 , Debora A Nicoll, Kenneth D Philipson
Affiliations
Review

The sodium/calcium exchanger family-SLC8

Beate D Quednau et al. Pflugers Arch. 2004 Feb.

Abstract

The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na(+) for 1 intracellular Ca(2+). In addition to transporting Na(+) and Ca(2+), NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.

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References

    1. Am J Physiol. 1999 Jul;277(1 Pt 2):H324-30 - PubMed
    1. Exp Cell Res. 2000 Mar 15;255(2):291-302 - PubMed
    1. Circ Res. 1999 Nov 26;85(11):982-4 - PubMed
    1. Pflugers Arch. 2000 Oct;440(6):819-27 - PubMed
    1. J Gen Physiol. 1997 Jun;109(6):717-29 - PubMed

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