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Review
. 2003 Mar;4(3):323-8.

Tezosentan. Actelion/Genentech

Enrico Rossetti  1 , Stefano De Servi
Affiliations
  • PMID: 12735233
Review

Tezosentan. Actelion/Genentech

Enrico Rossetti et al. Curr Opin Investig Drugs. 2003 Mar.

Abstract

Tezosentan is an endothelin receptor antagonist in development by Actelion Ltd and Genentech Inc for the potential treatment of cardiovascular disorders, including acute heart failure (AHF) and congestive heart failure. Actelion has conducted a phase III study of tezosentan in AHF patients, however, following disappointing trial results a new phase III study in AHF was planned using lower doses of the compound. By January 2003, Actelion anticipated that the first results of a two-year phase III study evaluating mortality/morbidity would be available by early 2005.

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