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. 2003 Mar;20(3):106-12.
doi: 10.1023/a:1022626823328.

Spermatogenic patterns and early embryo development after intracytoplasmic sperm injection in severe oligoasthenozoospermia

José M Vendrell  1 , Begoña Arán, Anna Veiga, Ferrán García, Buenaventura Coroleu, Susana Egozcue, Josep Egozcue, Pere N Barri
Affiliations

Spermatogenic patterns and early embryo development after intracytoplasmic sperm injection in severe oligoasthenozoospermia

José M Vendrell et al. J Assist Reprod Genet. 2003 Mar.

Abstract

Purpose: Evaluate the influence of different baseline spermatogenic patterns [meiotic pattern (normal or abnormal), sperm concentration (> 1 x 10(6)/mL or < or = 1 x 10(6)/mL), and the combined meiosis-sperm concentration pattern] on early embryo development in severe oligoasthenozoospermia.

Methods: Embryo outcomes (fertilization rate, cleavage rate, and 4-cell stage embryo division rate on day 2) after IVF-ICSI in 75 oligoasthenozoospermia and 79 normozoospermic males.

Results: The embryo division rate was significantly lower in oligoasthenozoospermia compared to normozoospermia (50.43% vs. 58.72%, p < 0.01) and in the oligoasthenozoospermia group for meiotic anomalies (43.40%), sperm concentration < or = 1 x 10(6)/mL (44.35%), and the combined pattern < or = 1 x 10(6)/mL with meiotic anomalies (37.17%). Logistic regression analysis showed a synergic effect (OR = 2.00; 95% CI = 1.28-3.12) when the two spermatogenic patterns predictive of slow embryo development [meiotic anomalies (OR = 1.49; 95% CI = 1.03-2.15) and sperm concentration < or = 1 x 10(6)/mL (OR = 1.53; 95% CI = 1.09-2.13)] were present.

Conclusions: The data suggest that the early embryonic developmental capacity is inversely related to the severity of spermatogenic impairment (meiotic anomalies and/or sperm concentration < or = 1 x 10(6)/mL).

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