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. 1976 Jun 4;192(4243):1018-20.
doi: 10.1126/science.1273584.

Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity

X O Breakefield, C M Castiglione, S B Edelstein

Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity

X O Breakefield et al. Science. .

Abstract

The Lesch-Nyhan syndrome in humans is characterized by lack of hypoxanthine phosphoribosyltransferase activity and neurologic abnormalities that suggest changes in catecholamine metabolism. Monoamine oxidase, which degrades biogenic amines, has decreased activity in noradrenergic murine neuroblastoma cell lines lacking hypoxanthine phosphoribosyltransferase activity and in skin fibroblasts from patients with the Lesch-Nyhan syndrome.

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