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. 1976 Jun 25;192(4246):1340-3.
doi: 10.1126/science.1273593.

Bone cells in culture: morphologic transformation by hormones

S S Miller, A M Wolf, C D Arnaud

Bone cells in culture: morphologic transformation by hormones

S S Miller et al. Science. .

Abstract

Hormones and purine nucleosides and nucleotides induced cultured bone cells to transform transiently from a spherical to a stellate shape. Cytochalasin B also induced the transformation. The change was blocked by colchicine and vinblastine, but not by lumicolchicine or cycloheximide. This morphologic transformation may provide a dynamic model of hormone action and bone cell modulation in vitro.

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