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Review
. 2003 Sep;13(9):77R-91R.
doi: 10.1093/glycob/cwg075. Epub 2003 May 7.

The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis

E Sergio Trombetta  1
Affiliations
Review

The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis

E Sergio Trombetta. Glycobiology. 2003 Sep.

Abstract

The attachment of N-glycans to nascent glycoproteins in the endoplasmic reticulum (ER) is intimately related to glycoprotein biogenesis. Processing of N-linked oligosaccharides begins in the ER and participates in glycoprotein folding and assembly. The elucidation of N-glycan processing mechanisms in the ER is uncovering their role in glycoprotein biosynthesis.

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