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. 2003 Jun;5(6):520-30.
doi: 10.1038/ncb990.

NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex

Nathalie Sans  1 , Kate Prybylowski, Ronald S Petralia, Kai Chang, Ya-Xian Wang, Claudia Racca, Stefano Vicini, Robert J Wenthold
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NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex

Nathalie Sans et al. Nat Cell Biol. 2003 Jun.

Abstract

NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Our results show that interactions between SAP102 and Sec8 are involved in the delivery of NMDARs to the cell surface in heterologous cells and neurons. Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking.

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  • The return of the exocyst.
    Hoogenraad CC, Sheng M. Hoogenraad CC, et al. Nat Cell Biol. 2003 Jun;5(6):493-5. doi: 10.1038/ncb0603-493. Nat Cell Biol. 2003. PMID: 12776120 No abstract available.

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