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Case Reports
. 2003 Jul;162(7-8):511-513.
doi: 10.1007/s00431-003-1212-0. Epub 2003 May 9.

Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea

Barbara Wildhaber  1   2 , Felix Niggli  3 , Eva Bergsträsser  3 , Thomas Stallmach  4 , Peter Sacher  5
Affiliations
Free article
Case Reports

Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea

Barbara Wildhaber et al. Eur J Pediatr. 2003 Jul.
Free article

Abstract

A paraneoplastic syndrome is occasionally the first clinical symptom seen with tumours. We report on two children who initially presented with paraneoplastic syndromes due to ganglioneuroblastomas: the first with severe watery diarrhoea caused by a ganglioneuroma producing vasoactive intestinal peptide, the second with non-treatable constipation, caused by ganglioneuroma-produced anti-neuronal nuclear antibodies.

Conclusion: Either severe diarrhoea or chronic constipation may represent rare paraneoplastic syndromes in ganglioneuroblastomas.

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