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. 2003 Jul 18;278(29):26788-92.
doi: 10.1074/jbc.M303468200. Epub 2003 May 9.

Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate

Toshikazu Shiba  1 , Daisuke Nishimura, Yumi Kawazoe, Yuichiro Onodera, Kaori Tsutsumi, Rie Nakamura, Minako Ohshiro
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Free article

Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate

Toshikazu Shiba et al. J Biol Chem. .
Free article

Abstract

The proliferation of normal human fibroblast cells was enhanced by the addition of inorganic polyphosphate (poly(P)) into culture media. The mitogenic activities of acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) were also enhanced by poly(P). A physical interaction between poly(P) and FGF-2 was observed, and FGF-2 was both physically and functionally stabilized by poly(P). Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs.

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