doi: 10.1038/nn1058.
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Affiliations
- PMID: 12740581
- DOI: 10.1038/nn1058
Item in Clipboard
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Nat Neurosci.
2003 Jun.
Abstract
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.
Similar articles
-
A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function.Neuron. 2005 Dec 22;48(6):1025-37. doi: 10.1016/j.neuron.2005.10.029. Neuron. 2005. PMID: 16364905
-
Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice.Eur J Neurosci. 2007 Feb;25(4):1205-11. doi: 10.1111/j.1460-9568.2007.05349.x. Eur J Neurosci. 2007. PMID: 17331216
-
Dopamine activity in the nucleus accumbens modulates blocking in fear conditioning.Eur J Neurosci. 2006 Dec;24(11):3265-70. doi: 10.1111/j.1460-9568.2006.05195.x. Eur J Neurosci. 2006. PMID: 17156387
-
GABAergic neurons: gate masters of the amygdala, mastered by dopamine.Neuron. 2005 Dec 22;48(6):877-9. doi: 10.1016/j.neuron.2005.12.002. Neuron. 2005. PMID: 16364892 Review.
-
Amygdala, long-term potentiation, and fear conditioning.Neuroscientist. 2005 Feb;11(1):75-88. doi: 10.1177/1073858404270857. Neuroscientist. 2005. PMID: 15632280 Review.
Cited by
-
A New Look at the Role of Mesoamygdaloid Dopamine Neurons in Aversive Conditioning.J Neurosci. 2020 Sep 30;40(40):7590-7592. doi: 10.1523/JNEUROSCI.1483-20.2020. J Neurosci. 2020. PMID: 32998956 Free PMC article. No abstract available.
-
Locus ceruleus activation suppresses feedforward interneurons and reduces beta-gamma electroencephalogram frequencies while it enhances theta frequencies in rat dentate gyrus.J Neurosci. 2005 Feb 23;25(8):1985-91. doi: 10.1523/JNEUROSCI.4307-04.2005. J Neurosci. 2005. PMID: 15728838 Free PMC article.
-
A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.J Neurosci. 2007 Oct 10;27(41):10947-56. doi: 10.1523/JNEUROSCI.2603-07.2007. J Neurosci. 2007. PMID: 17928436 Free PMC article.
-
Contribution of dopamine D1 and D2 receptors to amygdala activity in human.J Neurosci. 2010 Feb 24;30(8):3043-7. doi: 10.1523/JNEUROSCI.5689-09.2010. J Neurosci. 2010. PMID: 20181600 Free PMC article.
-
Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition.Elife. 2020 Jan 9;9:e50601. doi: 10.7554/eLife.50601. Elife. 2020. PMID: 31916940 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
