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Review
. 2003 May 8;38(3):361-2.
doi: 10.1016/s0896-6273(03)00257-5.

Actin's actions in LTP-induced synapse growth

John Lisman  1
Affiliations
Review

Actin's actions in LTP-induced synapse growth

John Lisman. Neuron. .

Abstract

F-actin is required for LTP induction, but the underlying mechanisms are unclear. New results show that LTP produces an increase in actin-rich spines. Furthermore, these spines have large synapses, strongly suggesting that LTP involves synapse growth. This process appears to require LIMK-1 phosphorylation of the actin depolymerizing factor cofilin.

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