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Clinical Trial
. 2003 May 13;60(9):1418-24.
doi: 10.1212/01.wnl.0000066683.34093.e2.

Idiopathic intracranial hypertension: the prevalence and morphology of sinovenous stenosis

R I Farb  1 , I Vanek, J N Scott, D J Mikulis, R A Willinsky, G Tomlinson, K G terBrugge
Affiliations
Clinical Trial

Idiopathic intracranial hypertension: the prevalence and morphology of sinovenous stenosis

R I Farb et al. Neurology. .

Abstract

Objective: To determine the prevalence and nature of sinovenous obstruction in idiopathic intracranial hypertension (IIH) using auto-triggered elliptic-centric-ordered three-dimensional gadolinium-enhanced MR venography (ATECO MRV).

Methods: In a prospective controlled study, 29 patients with established IIH as well as 59 control patients underwent ATECO MRV. In a randomized blinded fashion, three readers evaluated the images. Using a novel scoring system, each reader graded the degree of stenosis seen in the transverse and sigmoid sinuses of each patient.

Results: There was excellent agreement across the three readers for application of the grading system. Substantial bilateral sinovenous stenoses were seen in 27 of 29 patients with IIH and in only 4 of 59 control patients.

Conclusion: Using ATECO MRV and a novel grading system for quantifying sinovenous stenoses, the authors can identify IIH patients with sensitivity and specificity of 93%.

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