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. 2003 May;110(5):922-5.
doi: 10.1016/S0161-6420(03)00093-9.

Helicobacter pylori infection and the risk for open-angle glaucoma

Peter H Galloway  1 , Simon J Warner, Muhammad G Morshed, Frederick S Mikelberg
Affiliations

Helicobacter pylori infection and the risk for open-angle glaucoma

Peter H Galloway et al. Ophthalmology. 2003 May.

Abstract

Purpose: To determine the frequency of exposure to Helicobacter pylori infection in glaucoma patients.

Design: Prospective case-control study.

Participants: Ninety-seven consecutive patients attending a glaucoma clinic. These included 38 patients with primary open-angle glaucoma (POAG), 19 with normal pressure glaucoma (NPG), 16 with pseudoexfoliation glaucoma (PXE), and 24 with ocular hypertension (OHT). Ninety-four age-matched participants without glaucoma served as a control population.

Methods: Serum was analyzed for the presence of H. pylori-specific immunoglobulin G antibodies by enzyme-linked immunosorbent assay.

Main outcome measures: Serologic analysis for H. pylori.

Results: Seropositivity for H. pylori was higher in patients with glaucoma (26.0%) than in controls (20.2%), but this did not achieve statistical significance (P = 0.46). A total of 26.3% of POAG patients, 26.3% of NPG patients, 25.0% of PXE patients, and 25.0% of OHT patients were seropositive.

Conclusions: This study suggests that exposure to H. pylori infection is not associated with open-angle glaucoma.

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Comment in

  • Helicobacter pylori and glaucoma.
    Kountouras J, Zavos C, Chatzopoulos D. Kountouras J, et al. Ophthalmology. 2003 Dec;110(12):2433-4; author reply 2434. doi: 10.1016/j.ophtha.2003.09.014. Ophthalmology. 2003. PMID: 14644740 No abstract available.

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