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Case Reports
. 2003 Jul;18(7):710-1.
doi: 10.1007/s00467-003-1144-y. Epub 2003 May 16.

Lip hypertrophy secondary to cyclosporin treatment

Janette Christine Cansick  1 , Sally-Anne Hulton
Affiliations
Case Reports

Lip hypertrophy secondary to cyclosporin treatment

Janette Christine Cansick et al. Pediatr Nephrol. 2003 Jul.

Abstract

Gingival hypertrophy is a well-documented side effect of cyclosporin therapy, but severe lip enlargement is less frequently recognised. This can lead to poor body image, low self-esteem and non-compliance, especially in the older childhood and adolescent age groups. We describe two paediatric renal transplant recipients who had marked lip hypertrophy as a consequence of cyclosporin (Neoral) treatment. On changing the immunosuppression to tacrolimus (Prograf), this resolved. We recommend that a change in immunosuppressant therapy be considered in children with significant changes to facial appearance.

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