Apoptosis of granulosa cells: a review on the role of MAPK-signalling modules

Abstract

Recent studies suggest that ovarian follicular atresia is associated with DNA fragmentation and degeneration of granulosa cells, the hallmark of programmed cell death or apoptosis. Apoptosis of granulosa cells play a major role in follicular atresia. These studies have also demonstrated the involvement of tumour suppressors, apoptotic proteins and survival factors. These factors contribute to the developmental decision as to whether the ovarian follicles mature or undergo atresia. However, the precise temporal and molecular events involved in the apoptotic pathways in this process need to be elucidated. The present report summarizes the role of Jun N-terminal kinase (JNK), p38 mitogen activated protein kinase (p38 MAPK), and extracellular-signal regulated kinase (ERK)-signalling module in the regulation of pro- and anti-apoptotic factors of the granulosa cells in regulating follicular atresia. The findings presented here suggest that the loss of tropic hormone support is translated into the attenuation of Raf-1-MAPK/ERK kinase (MEK)-ERK-signalling pathway of the granulosa cells and this results in the decreased phosphorylation of the pro-apoptotic BAD.