Hide and seek: the immunology of HSV persistence
- PMID: 12753733
- DOI: 10.1016/s1074-7613(03)00121-3
Hide and seek: the immunology of HSV persistence
Abstract
Herpes simplex virus (HSV) has been thought to persist as a latent infection by completely extinguishing antigen expression. In this issue of Immunity, Khanna et al. challenge this view by showing that CTL specific for antigens normally associated with active viral replication are crucial participants in regulating virus latency.
Comment on
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Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia.Immunity. 2003 May;18(5):593-603. doi: 10.1016/s1074-7613(03)00112-2. Immunity. 2003. PMID: 12753737 Free PMC article.
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