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. 2003 May;18(5):643-54.
doi: 10.1016/s1074-7613(03)00110-9.

CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells

Mi-Yeon Kim  1 , Fabrina M C Gaspal, Helen E Wiggett, Fiona M McConnell, Adam Gulbranson-Judge, Chandra Raykundalia, Lucy S K Walker, Margaret D Goodall, Peter J L Lane
Affiliations
Free article

CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells

Mi-Yeon Kim et al. Immunity. 2003 May.
Free article

Abstract

In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo.

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