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Review
. 2003 May;61(5):887-90.

[Osteopontin and arthritis]

[Article in Japanese]
Masaki Noda  1 , Kenji Yumoto, Mikihiko Morinobu, Kunikazu Tsuji, Akira Nifuji
Affiliations
  • PMID: 12755020
Review

[Osteopontin and arthritis]

[Article in Japanese]
Masaki Noda et al. Nihon Rinsho. 2003 May.

Abstract

Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis. However, the functions of osteopontin in such diseased articular components have not yet been elucidated. Recent investigations using knockout mice lacking osteopontin indicated that the presence of osteopontin could play a role in the development of arthritis induced by injection with monoclonal antibodies raised against type II collagen.

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