Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 May;142(5):583-5.
doi: 10.1067/mpd.2003.203.

Glutathione metabolism and antioxidant enzymes in children with Down syndrome

Anna Pastore  1 , Giulia Tozzi, Laura Maria Gaeta, Aldo Giannotti, Enrico Bertini, Giorgio Federici, Maria Cristina Digilio, Fiorella Piemonte
Affiliations

Glutathione metabolism and antioxidant enzymes in children with Down syndrome

Anna Pastore et al. J Pediatr. 2003 May.

Abstract

Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

PubMed Disclaimer