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. 1976 Feb 1;153(2):491-3.
doi: 10.1042/bj1530491.

Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure

J Südi

Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure

J Südi. Biochem J. .

Abstract

On the basis of Ogston's [(1948) Nature (London) 162, 963] argument, the following conclusions are indicated by the stereochemistry of the reversible oxidation of glycollate by lactate dehydrogenase: (1) general acid-base catalysis is involved in the reaction; (2) the transformation of enzyme-bound (tetrahedral) substrate into enzyme-bound (trigonal) product involves a conformational transition of the enzyme-coenzyme complex.

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