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Comparative Study
. 1976 Jan 15;154(1):171-8.
doi: 10.1042/bj1540171.

Inhibition of protein synthesis in reticulocyte lysates by trichodermin

C J Carter, M Cannon, K E Smith
Comparative Study

Inhibition of protein synthesis in reticulocyte lysates by trichodermin

C J Carter et al. Biochem J. .

Abstract

1. The effect of trichodermin as an inhibitor of eukaryotic protein synthesis was studied in a reticulocyte cell-free system. 2. Trichodermin at a concentration of 25 mug/ml inhibits total protein synthesis instantaneously and stabilizes polyribosome profiles. Conversely, at a concentration of 0.25 mug/ml the drug inhibits total protein synthesis by only 70-75% and allows 30-35% breakdown of the polyribosomes in the system. These effects were compared with those produced by two other drugs (pactamycin and anisomycin) examined under conditions identical with those used for trichodermin.

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References

    1. Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Mar;71(3):713-7 - PubMed
    1. J Cell Physiol. 1973 Aug;82(1):121-8 - PubMed
    1. J Biol Chem. 1973 Nov 25;248(22):7970-2 - PubMed
    1. Mol Pharmacol. 1967 Sep;3(5):401-11 - PubMed

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