Apoptotic index and bcl-2 expression as prognostic factors in colorectal carcinoma
- PMID: 12759543
- DOI: 10.1159/000070304
Apoptotic index and bcl-2 expression as prognostic factors in colorectal carcinoma
Abstract
Objectives: To examine programmed cell death in 57 colorectal carcinomas (49 primary tumours and 8 metastases) and determine the prognostic significance of apoptosis in colorectal cancer.
Methods: Apoptotic index (AI) was ascertained by counting apoptotic bodies, using terminal deoxynucleotidyl transferase mediated digoxigenin nick end labelling (Tunel assay) and the expression of bcl-2 was examined immunohistochemically. Statistical analysis was used to test the value of clinical variables, histopathological data, AI and bcl-2 expression in predicting the clinical outcome of these patients and the survival function was calculated using the Kaplan-Meier method.
Results: AI was found to have a significant independent effect on survival (p = 0.0006), with lower values of AI conveying better survival.
Conclusion: In summary, these findings reveal that AI is a useful prognostic factor in colorectal carcinoma.
Copyright 2003 S. Karger AG, Basel
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