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Review
. 2000:65:21-9.
doi: 10.1101/sqb.2000.65.21.

Adaptive mutation in Escherichia coli

P L Foster  1
Affiliations
Review

Adaptive mutation in Escherichia coli

P L Foster. Cold Spring Harb Symp Quant Biol. 2000.
No abstract available

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Figures

Figure 1
Figure 1
A model for recombination-dependent mutation. (a–c) Collapse of the replication fork at oriT; (d–e) RecABCD-catalyzed invasion of the broken arm into the homologous sister chromosome; (f) establishment of the four-stranded Holliday junction and restoration of the replication fork; (g) translocation of the Holliday junction by RuvAB and/or RecG. Resolution of the Holliday junction by RuvC is not shown (see text for details). (Dashed lines) Newly synthesized DNA; (filled dashed lines) DNA synthesized during recombination. The arrowhead indicates the 3′ end of the leading DNA strand; the asterisk at oriT indicates TraI. For clarity, the invading strands have been abbreviated and flipped vertically between panels b and c.
Figure 2
Figure 2
Effects of DNA polymerase II, III, and IV on adaptive Lac+ mutation in E. coli strain FC40. Values are the mean (± SEM) number of Lac+ mutants appearing days 3–5 after plating. Several experiments have been combined, and each value represents from 12 to 23 determinations using our small-scale assay described in Foster et al. (1996).
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