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. 2003 Jun;47(6):2009-11.
doi: 10.1128/AAC.47.6.2009-2011.2003.

Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania

Daiva Bakonyte  1 , Aurelija Baranauskaite, Jurate Cicenaite, Anaida Sosnovskaja, Petras Stakenas
Affiliations

Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania

Daiva Bakonyte et al. Antimicrob Agents Chemother. 2003 Jun.

Abstract

Mutations at codon 315 of the katG gene were detected in 312 of 364 (85.7%) isoniazid-resistant Mycobacterium tuberculosis isolates. Seven of 52 (13.5%) isoniazid-resistant isolates with the wild-type Ser315 codon and 10 of 52 (19.2%) isoniazid-resistant isolates with a mutated katG allele had mutation -15C-->T in the promoter of the mabA-inhA operon.

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