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Review
. 2003 May 15;23(10):3981-9.
doi: 10.1523/JNEUROSCI.23-10-03981.2003.

Neuroimaging weighs in: humans meet macaques in "primate" visual cortex

Roger B H Tootell  1 , Doris Tsao, Wim Vanduffel
Affiliations
Review

Neuroimaging weighs in: humans meet macaques in "primate" visual cortex

Roger B H Tootell et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Maps of reported areas in primate visual cortex. Maps are shown on the flattened cortical surface from right hemisphere (light gray, gyri; dark gray, sulci). A shows areas in macaque reported by Van Essen and colleagues, and B shows the macaque areas reported by Ungerleider and collaborators (adapted from Van Essen et al., 2001). C shows areas in human visual cortex, as described in the text. Consensus is highest in lower-tier (generally, left-most) areas; such areas tend to be evolutionarily more conserved, and the retinotopy is more easily resolved.
Figure 2.
Figure 2.
Object-selective (LOc) activation in visual cortex of macaques and humans. In both species, fMRI (BOLD) data were acquired from awake subjects, who fixated the center of a common stimulus set. A shows those stimuli, presented in block design in an a–b–a–c sequence (a, 32 grid-scrambled objects; b, 32 different objects; c, one object, presented in two different views). B (macaque) and C (human) reveal regions activated more by objects than scrambled objects (red-orange) and the reverse (blue-cyan). D (macaque) and E (human) show corresponding fMRI levels in selected visual areas. The human region activated more by objects (C) has been named LOc; it corresponds primarily to higher-tier cortical areas TEO and TE in macaque (B). In both species, lower-tier retinotopic areas (e.g., V1, V2, V3) responded better to the control images (scrambled objects), making the reversal in higher-tier areas even more significant. In human LOc and macaque TEO/TE, there was a reduced response to presentations of the single object (condition c, dark gray) compared with the multiple objects (condition b, light gray). Thus macaque shows fMRI-based adaptation in inferotemporal cortex, similar to that in humans. Bold, Blood oxygen level dependent.
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