The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men
- PMID: 12764208
- DOI: 10.1097/01.psy.0000035719.79068.2b
The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men
Abstract
Objective: We examined the relation of severity of depressive symptoms to lipopolysaccharide-stimulated expression of monocyte-associated proinflammatory cytokines and chemokines in 53 nonsmoking, healthy men.
Methods: Assessments of cytokine and chemokine expression and severity of depressive symptoms were conducted on the same day. The 21-item Beck Depression Inventory (BDI) was used to assess severity of depressive symptoms experienced during the week before study participation. Dual-color flow cytometry was used to determine monocyte-associated (CD14+) expression of interleukin-1alpha (IL-1alpha), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and monocyte chemotactic protein-1 (MCP-1) after in vitro lipopolysaccharide stimulation of undiluted whole blood.
Results: Calculations of partial correlation coefficients controlling for age, race, body mass index, and alcohol use indicated that BDI score was significantly associated with IL-1alpha (r = 0.27), IL-1beta (r = 0.44), TNF-alpha (r = 0.57), MCP-1 (r = 0.52), and IL-8 (r = 0.33). In addition, relative to men with BDI scores below 10, men with BDI scores of 10 or above exhibited an overexpression of IL-1beta (p =.004), TNF-alpha (p =.005), IL-8 (p =.002), and MCP-1 (p =.025).
Conclusions: Relative to men with no or minimal symptoms of depression, men with mild to moderate levels of depressive symptoms showed overexpression of monocyte-associated proinflammatory cytokines and chemokines.
Similar articles
-
Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women.Psychoneuroendocrinology. 2004 Oct;29(9):1119-28. doi: 10.1016/j.psyneuen.2004.01.002. Psychoneuroendocrinology. 2004. PMID: 15219635 Clinical Trial.
-
Differential chemokine regulation by Th2 cytokines during human RPE-monocyte coculture.Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1631-8. Invest Ophthalmol Vis Sci. 2001. PMID: 11381071
-
Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: are immunosuppression regimens working?Transplantation. 2005 Feb 27;79(4):387-91. doi: 10.1097/01.tp.0000151631.66884.2e. Transplantation. 2005. PMID: 15729163
-
Possible impact of microglial cells and the monocyte-macrophage system on suicidal behavior.CNS Neurol Disord Drug Targets. 2013 Nov;12(7):971-9. doi: 10.2174/18715273113129990099. CNS Neurol Disord Drug Targets. 2013. PMID: 24040799 Review.
-
Inflammatory aspects of depression.Inflamm Allergy Drug Targets. 2008 Mar;7(1):19-23. doi: 10.2174/187152808784165216. Inflamm Allergy Drug Targets. 2008. PMID: 18473896 Review.
Cited by
-
Effects of Internet Cognitive-Behavioral Therapy on Depressive Symptoms and Surrogates of Cardiovascular Risk in Human Immunodeficiency Virus: A Pilot, Randomized, Controlled Trial.Open Forum Infect Dis. 2020 Jul 5;7(7):ofaa280. doi: 10.1093/ofid/ofaa280. eCollection 2020 Jul. Open Forum Infect Dis. 2020. PMID: 32760749 Free PMC article.
-
Serum cortisol, immunoglobulins and some complements among depressed patients.Indian J Clin Biochem. 2008 Jan;23(1):76-80. doi: 10.1007/s12291-008-0018-2. Epub 2008 Mar 6. Indian J Clin Biochem. 2008. PMID: 23105726 Free PMC article.
-
The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies.Inflammopharmacology. 2021 Feb;29(1):75-90. doi: 10.1007/s10787-020-00777-5. Epub 2020 Nov 8. Inflammopharmacology. 2021. PMID: 33164143 Review.
-
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats.Biol Sex Differ. 2024 Feb 13;15(1):16. doi: 10.1186/s13293-024-00589-0. Biol Sex Differ. 2024. PMID: 38350966 Free PMC article.
-
Loneliness and biological responses to acute stress in people with Type 2 diabetes.Psychophysiology. 2019 Jun;56(6):e13341. doi: 10.1111/psyp.13341. Epub 2019 Jan 28. Psychophysiology. 2019. PMID: 30693534 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous