Case Reports
doi: 10.1038/sj.thj.6200225.
Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22)
Affiliations
- PMID: 12764355
- DOI: 10.1038/sj.thj.6200225
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Case Reports
Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22)
Hematol J.
2003.
Abstract
We describe a case of acute myeloid leukemia (AML) with t(8;21) in which complete remission (CR) was obtained with G-CSF given at 10 microg/kg in the absence of concomitant cytotoxic chemotherapy. CR was achieved following 2 weeks of therapy and confirmed by investigating minimal residual disease by four-color flow cytometry analysis. During treatment with G-CSF, maturing cells with cytoplasmic Auer Rods were observed in the peripheral blood, suggesting a differentiation effect. This case adds further evidence for a specific role of G-CSF in the treatment of AML with t(8;21), namely in patients who are not eligible for aggressive chemotherapy.
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