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. 1976 May;57(1):149-51.
doi: 10.1111/j.1476-5381.1976.tb07665.x.

The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets

F Rendu

The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets

F Rendu. Br J Pharmacol. 1976 May.

Abstract

The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.

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