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. 2003 Jun;5(3):175-81.
doi: 10.1016/S1098-612X(03)00005-6.

Single-injection inulin clearance for routine measurement of glomerular filtration rate in cats

M Haller  1 , K Rohner, W Müller, F Reutter, H Binder, W Estelberger, P Arnold
Affiliations

Single-injection inulin clearance for routine measurement of glomerular filtration rate in cats

M Haller et al. J Feline Med Surg. 2003 Jun.

Abstract

Glomerular filtration rate (GFR) was determined in 53 cats using an inulin single-injection method. Thirty healthy young adult cats were used to establish normal values. The procedure was also used in 23 cats that were either older than 10 years or had borderline serum creatinine levels. The total clearance was calculated from the decay of the serum inulin concentration after injection of 3000 mg/m(2)body surface area using a two-compartment model. Concomitant inulin and iohexol clearance in nine cats showed excellent correlation between the two methods. Calculated normal values for GFR in 30 healthy cats were 35.9-58.5 (median 46.0) ml/min/m(2)or 2.07-3.69 (median 2.72) ml/min/kg. A few cats with normal creatinine or blood urea nitrogen levels were detected as having reduced GFR and therefore being in a state of early renal dysfunction. The study indicates that single-injection inulin clearance is a valuable tool for routine GFR measurement in cats. An "inulin excretion test" using only one blood sample 3h after the administration of 3000 mg/m(2)body surface area could prove an attractive alternative for the assessment of renal function in daily practice.

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Figures

Fig 1.
Fig 1.
Relationship between single-injection inulin clearance and iohexol clearance for simultaneous measurements in nine cats (r=0.9745).
Fig 2.
Fig 2.
Relationship between serum creatinine level and GFR in 23 cats of group B. Vertical line indicates lower limit of GFR normal values. Horizontal line indicates upper limit of serum creatinine normal values.
Fig 3.
Fig 3.
Relationship between serum BUN level and GFR in 23 cats of group B. Vertical line indicates lower limit of GFR normal values. Horizontal line indicates upper limit of serum BUN normal values.
Fig 4.
Fig 4.
Relationship between serum inulin level after 180 min and GFR in 23 cats of group B. Vertical line indicates lower limit of GFR normal values. Horizontal line indicates upper limit of serum inulin normal values after 180 min.
Fig 5.
Fig 5.
Relationship between urine specific gravity and GFR in all cats. Vertical line indicates lower limit of GFR normal values.
Fig 6.
Fig 6.
Relationship between urine specific gravity and serum creatinine level in all cats. Vertical line indicates upper limit of serum creatinine normal values.
See this image and copyright information in PMC

References

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